Does CBD make you high?
Authors: Gerhard Nahler, Franjo Grotenhermen, Antonio Waldo Zuardi, and José A.S. Crippa;
Department of Neuroscience and Behavior, University of São Paulo Ribeirão Preto, Brazil and Instituto
Nacional de Ciência e Tecnologia Translacional em Medicina
DOES CBD MAKE YOU HIGH?
|Does CBD make you high? Delta9-Tetrahydrocannabinol (“THC”) is a hurdle for CBD because THC is the primary psychoactive
component in cannabis. This close association between CBD and THC is likely what causes a negative
reaction to the thought of using CBD as a medical therapy.
studies on the subject. In fact, the researchers state that two particular prior studies “have caused much
confusion and uncertainty whether oral cannabidiol (CBD) is safe and whether subjects who are treated with
CBD run the risk of positive workplace tests [for THC].”
The Prior Studies questioning if CBD makes you high
|The first prior study analyzed the changes in CBD when mixed with a petri-dish simulation of stomach acids.
Interpretation of the results yielded the researcher conclusion that CBD does convert to THC when exposed to
The second prior study also suggested CBD may convert to THC when taken orally. The conclusion was based
on tests done on human volunteers.
The study authors noted that both prior studies were severely misinterpreted. This is due to two main reasons.
|1. While CBD might convert to THC under certain simulated acidic conditions, it has not been shown
to actually occur in living organisms. This is a classic misinterpretation of what could happen in
practicality based solely on culture-dish tests results.
2. The results of the human volunteer tests were taken out of context. Traces of THC were not only
extremely minimal in the human volunteers but the alleged THC was not present in urine samples.
Author Gerhard Nahler found it most surprising that an entire group of authors were “tempted to over-interpret
results.” However, he felt that misinterpretations are not entirely uncommon, stating “People overlook quite
frequently that “in vitro” results may differ significantly from conditions “in vivo”, particularly in man. In
vitro results are suggestions, not proofs for processes in real life.”
The current study points out that the glaring difference between CBD and THC is the inability for CBD to
bind to a person’s cannabinoid brain receptors (more scientifically referred to as “CB1”). As CBD does not
initiate a physiological response when combined with CB1, it “lacks cannabis-like intoxicating effects.”
The researchers note that while conversion to THC may occur under artificial conditions “Over 40 years of
research on CBD does not suggest a conversion of CBD to delta9-THC and/or other cannabinoids in vivo after
|To avoid misinterpretations in the future, Nahler noted “The more a result is unexpected (or presented as such
as it was in the paper of Merrick et al., 2016) the more authors should be cautious when interpreting and
|This is a truly impactful study for CBD use as it takes direct aim at the common-yet-faulty belief that CBD is a|
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