Afraid of Public-Speaking? CBD Might Help

Authors: Antonio W. Zuardi,Natália P. Rodrigues, Angélica L. Silva, Sandra A. Bernardo, Jaime E. C. Hallak, Francisco S. Guimarães, and José A. S. Crippa; University of São Paulo, National Institute of Science and Technology for Translational Medicine, National Council for Scientific and Technological Development

Fear of public speaking, also known as Glossophobia, is incredibly common and most people have experienced it at some point in their lives. This double-blind study involved a total of 60 males and females between the ages of 18 and 35. The subjects were divided into 5 groups who randomly received either a placebo, CBD in 100mg, 300mg or 900mg, or clonazepam (a medication used to treat panic disorders) following the experimental procedure in the graphic below:

Each participant gave a speech in front of the other participants, after which he or she again filled out the questionnaire on anxiety level (see graphic) and again had his or her blood pressure and heart rate taken.


Clonazepam was the obvious front runner, consistently reducing anxiety in a more sedative way than the placebos and CBD administration. However, CBD at a dosage of 300mg was shown to significantly reduce subjective anxiety in the post-speech phase. The same was not true for the 100mg and 900mg dosage. This study’s true focus was the varied dosage; seeking whether administration of CBD produces an “inverted U-Shaped dose response.”

We spoke with Antonio Zuardi, who told us this phrase “refers to a concept that a given drug is effective with an intermediate dose, but not with smaller or larger doses.” CBD did indeed produce such a response. As such, Zuardi noted that “These findings stress the importance of the careful choice of dose ranges when investigating the potential therapeutic effects of CBD.”

The dosing is obviously vital but the real-life impact of this study is that CBD could be used to manage anxiety.

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